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The college's library was looted and its sole building requisitioned for use as a military hospital first by American and then British forces.

Loyalists were forced to abandon their King's College in New York, which was seized by the rebels and renamed Columbia College.

There are nearby institutions that are affiliated with Columbia including Barnard College, List College, and Union Theological Seminary.

Neuroscience research at Columbia has a rich history dating back to the founding of the Neurological Institute in Manhattan in 1909.

The Institute moved to Washington Heights as an affiliate of the Columbia University Medical Center in 1929. D., Professor of Neuroscience and Pharmacology, and includes 35 faculty members.

The Department was founded in 2007 replacing the more broadly based Center for Neurobiology and Behavior. Among them are two Nobel Prize winners Eric Kandel (2000) and Richard Axel (2004); five Howard Hughes Medical Institute investigators; eight members of the National Academy of Sciences; and 13 members of the Institute of Medicine of the National Academies.

The textbook Principles of Neural Science, which counts numerous Columbia faculty as co-authors, is the most widely used neuroscience text in the world.

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Both President George Washington and Vice President John Adams attended the college's commencement on May 6, 1789, as a tribute of honor to the many alumni of the school who had been involved in the American Revolution.